weight loss

Effects of Metabolic Adaptation to Weight Loss For Dieters

Over the decades, the prevalence of obesity has increased significantly. In the United States, more than two in three adults are considered overweight or obese. A similar proportion of men in the European Union is also affected. Trying to lose weight is a growing demand all over the world.

While moderate weight loss can improve metabolic health, low-calorie diets are notoriously difficult to maintain. Dieters should try to rebalance their caloric needs after losing weight to maintain their weight loss and prevent adaptive thermogenesis from having a significant effect on them.

Recent research has shown that metabolic adaptation (adaptive thermogenesis) can make a difference in the ability of obese people to lose body weight. Metabolic adaptation after massive weight loss is linked to the degree of energy imbalance and changes in circulating leptin.


Scientists at the University of Newcastle have performed the following experimental tests.

1) Objectives:

Weight loss is associated with a decrease in total energy expenditure and at rest. The objective is to determine whether  diets with different rates and degrees of weight loss have determined different changes in total energy expenditure and at rest and whether  have influenced the level of adaptive thermogenesis defined since the fall in Total energy expenditure or rest do not take into account changes in body composition.

2) Method:

Three groups of six obese men will fast for a total of 6 days to achieve 5% weight loss. Thanks to a low-calorie diet (2.5 MJ / day) for 3 weeks and a low-calorie diet (5.2 MJ / day) for 6 weeks to achieve a weight loss of 10%. A four component model will be used to measure body composition. Indirect calorimetry will be used to measure energy expenditure at rest.

The total energy expenditure will be measured by double water labeled for the very low calorie diet and the low calorie diet, and the calorimetry of the whole body for 24 hours (on an empty stomach).

3) Results:

Three groups of overweight men dieted. The first group experienced the most difficult period. They went on an extreme diet for only six days. The second group followed a slightly easier weak diet for 3 weeks. The third group followed an even easier calorie diet for 6 weeks.

All of the groups ended up losing about 5% of their body weight. (About 10 pounds). The difference is how long it took. The first group lost 10 pounds in just 6 days! The second group did it in 3 weeks. The third group did it in 6 weeks.

The very low-calorie diet and the low-calorie diet showed a similar degree of metabolic adaptation for total energy expenditure (very low calories = - 6.2%; low calories = - 6.8%). The metabolic adaptation for resting energy expenditure was greater in the LCD group (- 0.4 MJ / day, - 5.3%) than in the high-calorie diet group (- 0.1 MJ / day, - 1, 4%).

The energy expenditure at rest did not decrease after a rapid fast and no evidence of adaptive thermogenesis (+ 0.4 MJ / day) was found after a weight loss of 5%. The rate of weight loss was inversely associated with changes in resting energy expenditure (n = 30, r = 0.42, p = 0.01).

4. Conclusions:

The rate of weight loss does not seem to have influenced the decrease in total energy expenditure in obese men after a weight loss of 10%. About 6% of this decrease in total energy expenditure is explained by the mechanisms of adaptive thermogenesis.

Resting metabolism decreased PLUS in the 6 week diet group. The 3-week diet group experienced the second largest decrease in resting metabolism. And the 6-day "extreme diet group" saw the smallest drop in resting metabolism. Therefore, losing fat slowly is horrible for your metabolism.

According to the results of experimental tests, it is "yes positive" that faster fat loss is better for your metabolism.

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